Article

Human transmembrane protein 68 links triacylglycerol synthesis to membrane lipid homeostasis

2024-04-14

Abstract excerpt

Transmembrane protein 68 (TMEM68) is a recently identified mammalian triacylglycerol (TAG) synthase with high expression in the brain. How TMEM68 regulates cellular lipid metabolism in concert with other enzymatic pathways remains poorly understood. In this study, we assessed TMEM68 function in neuro- and gliablastoma cells by combining genetic gain- and loss-of-function approaches with lipidomics. We found that T...

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Literature Corpus work: 38435de9-cfd8-51e7-bbef-b5d102285ae6
DOI: 10.1101/2024.04.14.589399

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