Article
Interleukin-18 promoter -137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients.
Clinical biochemistry - 1 Jun 2020
Cavalcante Jânio Emanuel Andrade, de Sousa Ederson Laurindo Holanda, de Oliveira Rodrigues Raphael, de Almeida Viana Glautemberg, Duarte Gadelha Daniel, de Carvalho Manoela Montenegro Dias, Sousa Duaran Lopes, Silva Allysson Jordan Xavier, Filho Raimundo Rigoberto Barbosa Xavier, Fernandes Virgínia Oliveira, Montenegro Júnior Renan Magalhães, de Sousa Alves Renata, Meneses Gdayllon Cavalcante, Sampaio Tiago Lima, Queiroz Maria Goretti Rodrigues
Abstract excerpt
BACKGROUND: Interleukin-18 (IL-18), a proinflammatory and proatherogenic cytokine, has been associated with type 2 diabetes, metabolic syndrome, stroke and coronary artery disease. Some studies have indicated that the IL-18 promoter -137 G/C polymorphism seems to be associated with changes in the IL-18 expression and may contribute to the development of cardiovascular disease (CVD). The aim of this study was to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.