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Interleukin-18 promoter polymorphisms in type 1 diabetes.

Diabetes - 1 Nov 2002

Kretowski Adam, Mironczuk Katarzyna, Karpinska Anna, Bojaryn Urszula, Kinalski Maciej, Puchalski Zbigniew, Kinalska Ida

Abstract excerpt

Type 1 diabetes is believed to be a Th1 lymphocyte-mediated disease, and both environmental and genetic factors play a role in its pathogenesis. It was recently found that interleukin (IL)-18 acts as a proinflammatory cytokine and, in synergy with IL-12, promotes development of Th1 lymphocyte response by induction of gamma-interferon production. The aim of our study was to evaluate the frequency of known...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12401730
DOI: 10.2337/diabetes.51.11.3347

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