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Article

Targeted disruption of Cd40 in a genetically hypertensive rat model attenuates renal fibrosis and proteinuria, independent of blood pressure.

Kidney international - 1 Feb 2017

Haller Steven T, Kumarasamy Sivarajan, Folt David A, Wuescher Leah M, Stepkowski Stanislaw, Karamchandani Manish, Waghulde Harshal, Mell Blair, Chaudhry Muhammad, Maxwell Kyle, Upadhyaya Siddhi, Drummond Christopher A, Tian Jiang, Filipiak Wanda E, Saunders Thomas L, Shapiro Joseph I, Joe Bina, Cooper Christopher J

Abstract excerpt

High blood pressure is a common cause of chronic kidney disease. Because CD40, a member of the tumor necrosis factor receptor family, has been linked to the progression of kidney disease in ischemic nephropathy, we studied the role of Cd40 in the development of hypertensive renal disease. The Cd40 gene was mutated in the Dahl S genetically hypertensive rat with renal disease by targeted-gene disruption using...

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Identifiers

PMID: 27692815
DOI: 10.1016/j.kint.2016.08.015
PMCID: PMC5237403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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