Article
Calmodulin mutant in central linker reduces the binding affinity with PreIQ and IQ while interacting with CaV1.2 channels.
Biochemical and biophysical research communications - 21 May 2020
Liu Yan, Yan Shan, Chen Sichong, Zhang Jie, Shen Yixuan, Su Jingyang, He Guilin, Feng Rui, Shao Dongxue, Hao Liying
Abstract excerpt
Calmodulin (CaM) was reported to interact with PreIQ and IQ of CaV1.2 channels, but to date, no explicit binding sites of CaM were illustrated. Therefore, in the present study, we firstly used MOE (Molecular Operating Environment) for protein-protein docking and we found that the most likely residues of CaM that play an important role in the interface are concentrated in central linker region. Next we examined...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.