Article
Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.
Gut - 1 Feb 2023
Buch Stephan, Innes Hamish, Lutz Philipp Ludwig, Nischalke Hans Dieter, Marquardt Jens U, Fischer Janett, Weiss Karl Heinz, Rosendahl Jonas, Marot Astrid, Krawczyk Marcin, Casper Markus, Lammert Frank, Eyer Florian, Vogel Arndt, Marhenke Silke, von Felden Johann, Sharma Rohini, Atkinson Stephen Rahul, McQuillin Andrew, Nattermann Jacob, Schafmayer Clemens, Franke Andre, Strassburg Christian, Rietschel Marcella, Altmann Heidi, Sulk Stefan, Thangapandi Veera Raghavan, Brosch Mario, Lackner Carolin, Stauber Rudolf E, Canbay Ali, Link Alexander, Reiberger Thomas, Mandorfer Mattias, Semmler Georg, Scheiner Bernhard, Datz Christian, Romeo Stefano, Ginanni Corradini Stefano, Irving William Lucien, Morling Joanne R, Guha Indra Neil, Barnes Eleanor, Ansari M Azim, Quistrebert Jocelyn, Valenti Luca, Müller Sascha A, Morgan Marsha Yvonne, Dufour Jean-François, Trebicka Jonel, Berg Thomas, Deltenre Pierre, Mueller Sebastian, Hampe Jochen, Stickel Felix
Abstract excerpt
OBJECTIVE: Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence. This study aimed to identify novel susceptibility loci for the development of HCC in people with alcohol related cirrhosis. DESIGN: Patients with alcohol-related...
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