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Article

Cerebral cavernous malformation (CCM) disease: from monogenic forms to genetic susceptibility factors.

Journal of neurosurgical sciences - 1 Sept 2015

Trapani E, Retta S F

Abstract excerpt

Cerebral cavernous malformation (CCM) is a vascular disease of proven genetic origin, which may arise sporadically or can be inherited as autosomal dominant condition with incomplete penetrance and highly variable expressivity. CCM lesions manifest across a range of different phenotypes, including wide interindividual differences in lesion number, size and susceptibility to intracerebral hemorrhage (ICH), and may...

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PMID: 25896717

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