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Article

Cerebral cavernous malformation (CCM) disease: from monogenic forms to genetic susceptibility factors.

Journal of neurosurgical sciences - 1 Sept 2015

Trapani E, Retta S F

Abstract excerpt

Cerebral cavernous malformation (CCM) is a vascular disease of proven genetic origin, which may arise sporadically or can be inherited as autosomal dominant condition with incomplete penetrance and highly variable expressivity. CCM lesions manifest across a range of different phenotypes, including wide interindividual differences in lesion number, size and susceptibility to intracerebral hemorrhage (ICH), and may...

Topics

Central Nervous System Neoplasms
Genetic Predisposition to Disease
Hemangioma, Cavernous, Central Nervous System
Humans

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25896717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25896717-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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