Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Notch3 is necessary for blood vessel integrity in the central nervous system.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2015

Henshall Tanya L, Keller Annika, He Liqun, Johansson Bengt R, Wallgard Elisabet, Raschperger Elisabeth, Mäe Maarja Andaloussi, Jin Shaobo, Betsholtz Christer, Lendahl Urban

Abstract excerpt

OBJECTIVE: Vascular smooth muscle cells (VSMC) are important for contraction, blood flow distribution, and regulation of blood vessel diameter, but to what extent they contribute to the integrity of blood vessels and blood-brain barrier function is less well understood. In this report, we explored the impact of the loss of VSMC in the Notch3(-/-) mouse on blood vessel integrity in the central nervous system....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood-Brain Barrier
Share to Blood Vessels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capillary Permeability

Share to Microvessels

Share to Pericytes

Share to Receptor, Notch3

Share to Receptors, Notch

Share to Retinal Vessels

Source

Identifiers

PMID: 25477343
DOI: 10.1161/ATVBAHA.114.304849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notch3 is necessary for blood vessel integrity in the central nervous system.PMID 25477343Read ↗

Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice.Semantic proximity Read ↗

Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL and results in arteriovenous malformationsSemantic proximity Read ↗

Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage.Semantic proximity Read ↗

Mural cells protect the adult brain from hemorrhage but do not control the blood-brain barrier in developing zebrafishSemantic proximity Read ↗

Endolysosomal dysfunction in radial glia progenitor cells leads to defective cerebral angiogenesis and compromised Blood-Brain Barrier integritySemantic proximity Read ↗

Notch3 establishes brain vascular integrity by regulating pericyte number.Semantic proximity Read ↗

Notch signalling in smooth muscle cells during development and disease.Semantic proximity Read ↗

Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature.Semantic proximity Read ↗

notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish.Semantic proximity Read ↗

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.Semantic proximity Read ↗

Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and PericytesSemantic proximity Read ↗

Neural Regulation of Vascular Development: Molecular Mechanisms and InteractionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.