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Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer.

Genes - 14 Mar 2020

Rantapero Tommi, Wahlfors Tiina, Kähler Anna, Hultman Christina, Lindberg Johan, Tammela Teuvo Lj, Nykter Matti, Schleutker Johanna, Wiklund Fredrik

Abstract excerpt

Germline variants in DNA repair genes are associated with aggressive prostate cancer (PrCa). The aim of this study was to characterize germline variants in DNA repair genes associated with lethal PrCa in Finnish and Swedish populations. Whole-exome sequencing was performed for 122 lethal and 60 unselected PrCa cases. Among the lethal cases, a total of 16 potentially damaging protein-truncating variants in DNA...

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DNA Repair
Exome Sequencing
Finland
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

Prostatic Neoplasms

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Identifiers

PMID: 32183364
DOI: 10.3390/genes11030314
PMCID: PMC7140841

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