Article
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
The New England journal of medicine - 4 Aug 2016
Pritchard Colin C, Mateo Joaquin, Walsh Michael F, De Sarkar Navonil, Abida Wassim, Beltran Himisha, Garofalo Andrea, Gulati Roman, Carreira Suzanne, Eeles Rosalind, Elemento Olivier, Rubin Mark A, Robinson Dan, Lonigro Robert, Hussain Maha, Chinnaiyan Arul, Vinson Jake, Filipenko Julie, Garraway Levi, Taplin Mary-Ellen, AlDubayan Saud, Han G Celine, Beightol Mallory, Morrissey Colm, Nghiem Belinda, Cheng Heather H, Montgomery Bruce, Walsh Tom, Casadei Silvia, Berger Michael, Zhang Liying, Zehir Ahmet, Vijai Joseph, Scher Howard I, Sawyers Charles, Schultz Nikolaus, Kantoff Philip W, Solit David, Robson Mark, Van Allen Eliezer M, Offit Kenneth, de Bono Johann, Nelson Peter S
Abstract excerpt
BACKGROUND: Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes among men with localized prostate cancer who are unselected for family predisposition is insufficient to warrant routine testing, the frequency of such mutations in patients with metastatic prostate cancer has not been...
Topics
- Age Factors
- Aged
- Aged, 80 and over
- DNA Mutational Analysis
- DNA Repair
- Genetic Predisposition to Disease