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Article

Identification of Genes with Rare Loss of Function Variants Associated with Aggressive Prostate Cancer and Survival.

European urology oncology - 1 Apr 2024

Saunders Edward J, Dadaev Tokhir, Brook Mark N, Wakerell Sarah, Govindasami Koveela, Rageevakumar Reshma, Hussain Nafisa, Osborne Andrea, Keating Diana, Lophatananon Artitaya, Muir Kenneth R, Darst Burcu F, Conti David V, Haiman Christopher A, Antoniou Antonis C, Eeles Rosalind A, Kote-Jarai Zsofia

Abstract excerpt

BACKGROUND: Prostate cancer (PrCa) is a substantial cause of mortality among men globally. Rare germline mutations in BRCA2 have been validated robustly as increasing risk of aggressive forms with a poorer prognosis; however, evidence remains less definitive for other genes. OBJECTIVE: To detect genes associated with PrCa aggressiveness, through a pooled analysis of rare variant sequencing data from six...

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Identifiers

PMID: 38458890
DOI: 10.1016/j.euo.2024.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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