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Article

Rare germline genetic variants and risk of aggressive prostate cancer.

International journal of cancer - 15 Oct 2020

Nguyen-Dumont Tú, MacInnis Robert J, Steen Jason A, Theys Derrick, Tsimiklis Helen, Hammet Fleur, Mahmoodi Maryam, Pope Bernard J, Park Daniel J, Mahmood Khalid, Severi Gianluca, Bolton Damien, Milne Roger L, Giles Graham G, Southey Melissa C

Abstract excerpt

Few genetic risk factors have been demonstrated to be specifically associated with aggressive prostate cancer (PrCa). Here, we report a case-case study of PrCa comparing the prevalence of germline pathogenic/likely pathogenic (P/LP) genetic variants in 787 men with aggressive disease and 769 with nonaggressive disease. Overall, we observed P/LP variants in 11.4% of men with aggressive PrCa and 9.8% of men with...

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PMID: 32338768
DOI: 10.1002/ijc.33024

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