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Article

Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer.

Journal of the National Cancer Institute - 4 May 2021

Darst Burcu F, Dadaev Tokhir, Saunders Ed, Sheng Xin, Wan Peggy, Pooler Loreall, Xia Lucy Y, Chanock Stephen, Berndt Sonja I, Gapstur Susan M, Stevens Victoria, Albanes Demetrius, Weinstein Stephanie J, Gnanapragasam Vincent, Giles Graham G, Nguyen-Dumont Tu, Milne Roger L, Pomerantz Mark, Schmidt Julie A, Mucci Lorelei, Catalona William J, Hetrick Kurt N, Doheny Kimberly F, MacInnis Robert J, Southey Melissa C, Eeles Rosalind A, Wiklund Fredrik, Kote-Jarai Zsofia, Conti David V, Haiman Christopher A

Abstract excerpt

BACKGROUND: There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely pathogenic, or deleterious (P/LP/D) germline variants in DNA repair genes are associated with aggressive PCa risk in a case-case study of aggressive vs nonaggressive disease. METHODS: Participants were 5545 European-ancestry men, including 2775...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32853339
DOI: 10.1093/jnci/djaa132
PMCID: PMC8599772

Genes

ATM
BRCA2
PALB2

Provenance

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