Article
Multiple Novel Mutations in Plasmodium falciparum Chloroquine Resistance Transporter Gene during Implementation of Artemisinin Combination Therapy in Thailand.
The American journal of tropical medicine and hygiene - 1 Oct 2018
Buppan Pattakorn, Seethamchai Sunee, Kuamsab Napaporn, Harnyuttanakorn Pongchai, Putaporntip Chaturong, Jongwutiwes Somchai
Abstract excerpt
Mutations in the chloroquine resistance transporter gene of Plasmodium falciparum (Pfcrt) are associated with drug susceptibility status of chloroquine and other antimalarials that interfere with heme detoxification process including artemisinin. We aim to investigate whether an increase in duration of artemisinin combination therapy (ACT) in Thailand could affect mutations in Pfcrt. The complete coding sequences...
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