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Article

Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function.

Life science alliance - 1 Apr 2020

Koussis Konstantinos, Withers-Martinez Chrislaine, Baker David A, Blackman Michael J

Abstract excerpt

Over recent years, a plethora of new genetic tools has transformed conditional engineering of the malaria parasite genome, allowing functional dissection of essential genes in the asexual and sexual blood stages that cause pathology or are required for disease transmission, respectively. Important challenges remain, including the desirability to complement conditional mutants with a correctly regulated second...

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Share to Cyclic GMP-Dependent Protein Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32179592
DOI: 10.26508/lsa.201900626
PMCID: PMC7081069

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