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The dimerisable Cre recombinase allows conditional genome editing in the mosquito stages of Plasmodium berghei

12 Oct 2020

Abstract excerpt

Asexual blood stages of the malaria parasite are readily amenable to genetic modification via homologous recombination, allowing functional studies of parasite genes that are not essential in this part of the life cycle. However, conventional reverse genetics cannot be applied for the functional analysis of genes that are essential during asexual blood-stage replication. Various strategies have been developed for...

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Complement system in diseases
CRISPR and Genetic Engineering
Malaria Research and Control

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33044964
DOI: 10.1371/journal.pone.0236616

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