Article

Investigations into phosphodieterases as targets for antimalarial drug discovery

2015-01-01

Abstract excerpt

Phosphodiesterases are key enzymes in cyclic-nucleotide signalling pathways, regulating the levels of cAMP and cGMP in the cell. Cyclic nucleotides play an important role in regulating progression of the complex parasite life cycle. There are four Plasmodium PDEs, PDEα-δ. PDEβ has proved refractory to deletion and is predicted to be essential in asexual blood stages. PDEs α, γ and δ have been successfully disrupte...

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Literature Corpus work: 21c76b0a-bb55-59a5-bf65-0b46d8dbd326
DOI: 10.17037/pubs.02305376

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