Robust inducible Cre recombinase activity in the human malaria parasite P lasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle

Abstract excerpt

Asexual blood stages of the malaria parasite, which cause all the pathology associated with malaria, can readily be genetically modified by homologous recombination, enabling the functional study of parasite genes that are not essential in this part of the life cycle. However, no widely applicable method for conditional mutagenesis of essential asexual blood-stage malarial genes is available, hindering their...

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