Article

Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites

2024-02-04

Abstract excerpt

The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically relevant asexual blood stages, many aspects of malarial PKG regulation, including the importance of phosphorylation, remain poorly understood. Here we use genetic and bioc...

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Literature Corpus work: 9b424d53-9336-539f-b94b-495ee50aca8c
DOI: 10.1101/2024.02.04.578801

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