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Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

8 Oct 2018

Abstract excerpt

In malaria parasites, evolution of parasitism has been linked to functional optimisation. Despite this optimisation, most members of a calcium-dependent protein kinase (CDPK) family show genetic redundancy during erythrocytic proliferation. To identify relationships between phospho-signalling pathways, we here screen 294 genetic interactions among protein kinases in Plasmodium berghei. This reveals a synthetic...

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PMID: 30315162
DOI: 10.1038/s41467-018-06733-w

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