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A scaleable inducible knockout system for studying essential gene function in the malaria parasite

12 Dec 2024

Abstract excerpt

The malaria parasite needs nearly half of its genes to propagate normally within red blood cells. Inducible ways to interfere with gene expression like the DiCre-lox system are necessary to study the function of these essential genes. However, existing DiCre-lox strategies are not well-suited to be deployed at scale to study several genes simultaneously. To overcome this, we have developed SHIFTiKO...

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CRISPR and Genetic Engineering
Malaria Research and Control
Mosquito-borne diseases and control

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39739757
DOI: 10.1093/nar/gkae1274

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