Article
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
Nature genetics - 1 Nov 2009
Ganesh Santhi K, Zakai Neil A, van Rooij Frank J A, Soranzo Nicole, Smith Albert V, Nalls Michael A, Chen Ming-Huei, Kottgen Anna, Glazer Nicole L, Dehghan Abbas, Kuhnel Brigitte, Aspelund Thor, Yang Qiong, Tanaka Toshiko, Jaffe Andrew, Bis Joshua C M, Verwoert Germaine C, Teumer Alexander, Fox Caroline S, Guralnik Jack M, Ehret Georg B, Rice Kenneth, Felix Janine F, Rendon Augusto, Eiriksdottir Gudny, Levy Daniel, Patel Kushang V, Boerwinkle Eric, Rotter Jerome I, Hofman Albert, Sambrook Jennifer G, Hernandez Dena G, Zheng Gang, Bandinelli Stefania, Singleton Andrew B, Coresh Josef, Lumley Thomas, Uitterlinden André G, Vangils Janine M, Launer Lenore J, Cupples L Adrienne, Oostra Ben A, Zwaginga Jaap-Jan, Ouwehand Willem H, Thein Swee-Lay, Meisinger Christa, Deloukas Panos, Nauck Matthias, Spector Tim D, Gieger Christian, Gudnason Vilmundur, van Duijn Cornelia M, Psaty Bruce M, Ferrucci Luigi, Chakravarti Aravinda, Greinacher Andreas, O'Donnell Christopher J, Witteman Jacqueline C M, Furth Susan, Cushman Mary, Harris Tamara B, Lin Jing-Ping
Abstract excerpt
Measurements of erythrocytes within the blood are important clinical traits and can indicate various hematological disorders. We report here genome-wide association studies (GWAS) for six erythrocyte traits, including hemoglobin concentration (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and red blood cell count (RBC). We...
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