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Article

Leveraging trans-ethnic genetic risk scores to improve association power for complex traits in underrepresented populations.

Briefings in bioinformatics - 20 Jul 2023

Lu Haojie, Zhang Shuo, Jiang Zhou, Zeng Ping

Abstract excerpt

Trans-ethnic genome-wide association studies have revealed that many loci identified in European populations can be reproducible in non-European populations, indicating widespread trans-ethnic genetic similarity. However, how to leverage such shared information more efficiently in association analysis is less investigated for traits in underrepresented populations. We here propose a statistical framework,...

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PMID: 37332016
DOI: 10.1093/bib/bbad232

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