Article
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
Human molecular genetics - 15 Jun 2013
Chen Zhao, Tang Hua, Qayyum Rehan, Schick Ursula M, Nalls Michael A, Handsaker Robert, Li Jin, Lu Yingchang, Yanek Lisa R, Keating Brendan, Meng Yan, van Rooij Frank J A, Okada Yukinori, Kubo Michiaki, Rasmussen-Torvik Laura, Keller Margaux F, Lange Leslie, Evans Michele, Bottinger Erwin P, Linderman Michael D, Ruderfer Douglas M, Hakonarson Hakon, Papanicolaou George, Zonderman Alan B, Gottesman Omri, Thomson Cynthia, Ziv Elad, Singleton Andrew B, Loos Ruth J F, Sleiman Patrick M A, Ganesh Santhi, McCarroll Steven, Becker Diane M, Wilson James G, Lettre Guillaume, Reiner Alexander P
Abstract excerpt
Laboratory red blood cell (RBC) measurements are clinically important, heritable and differ among ethnic groups. To identify genetic variants that contribute to RBC phenotypes in African Americans (AAs), we conducted a genome-wide association study in up to ~16 500 AAs. The alpha-globin locus on chromosome 16pter [lead SNP rs13335629 in ITFG3 gene; P < 1E-13 for hemoglobin (Hgb), RBC count, mean corpuscular...
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