Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variant in CACNA1C is associated with PTSD in traumatized police officers.

European journal of human genetics : EJHG - 1 Feb 2018

Krzyzewska Izabela M, Ensink Judith B M, Nawijn Laura, Mul Adri N, Koch Saskia B, Venema Andrea, Shankar Vinod, Frijling Jessie L, Veltman Dirk J, Lindauer Ramon J L, Olff Miranda, Mannens Marcel M A M, van Zuiden Mirjam, Henneman Peter

Abstract excerpt

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder that may develop after a traumatic event. Here we aimed to identify epigenetic and genetic loci associated with PTSD. We included 73 traumatized police officers with extreme phenotypes regarding symptom severity despite similar trauma history: n = 34 had PTSD and n = 39 had minimal PTSD symptoms. Epigenetic and genetic profiles were based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Calcium Channels, L-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to CpG Islands

Share to DNA Methylation

Share to PAX8 gene

Share to Polymorphism, Single Nucleotide

Share to Stress Disorders, Post-Traumatic

Source

Open in PubMed Open full text

Identifiers

PMID: 29362489
DOI: 10.1038/s41431-017-0059-1
PMCID: PMC5838973

Genes

PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variant in CACNA1C is associated with PTSD in traumatized police officers.PMID 29362489Read ↗

Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohortsSemantic proximity Read ↗

Prominent genetic variants and epigenetic changes in post-traumatic stress disorder among combat veterans.Semantic proximity Read ↗

Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies novel methylation lociSemantic proximity Read ↗

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran SampleSemantic proximity Read ↗

Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative.Semantic proximity Read ↗

Meta-analysis of longitudinal epigenome-wide association studies of military cohorts reveals multiple CpG sites associated with post-traumatic stress disorderSemantic proximity Read ↗

Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.Semantic proximity Read ↗

Recent Genetics and Epigenetics Approaches to PTSD.Semantic proximity Read ↗

Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veteransSemantic proximity Read ↗

Epigenetic factors in posttraumatic stress disorder resilience and susceptibilitySemantic proximity Read ↗

Mapping the epigenomic landscape of post-traumatic stress disorder in human cortical neuronsSemantic proximity Read ↗

Genetic Advances in Post-traumatic Stress Disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.