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Article

Genetic and childhood trauma interaction effect on age of onset in bipolar disorder: An exploratory analysis.

Journal of affective disorders - 1 Jul 2015

Anand Amit, Koller Daniel L, Lawson William B, Gershon Elliot S, Nurnberger John I

Abstract excerpt

INTRODUCTION: This study investigated whether early life trauma mediates genetic effects on the age at onset (AAO) of bipolar disorder. METHOD: Data from the BiGS Consortium case samples (N=1119) were used. Childhood traumatic events were documented using the Childhood Life Events Scale (CLES). Interaction between occurrence of childhood trauma and common genetic variants throughout the genome was tested to...

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Identifiers

PMID: 25837715
DOI: 10.1016/j.jad.2015.02.029
PMCID: PMC5845791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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