CREB1 gene polymorphisms combined with environmental risk factors increase susceptibility to major depressive disorder (MDD).

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Article

CREB1 gene polymorphisms combined with environmental risk factors increase susceptibility to major depressive disorder (MDD).

International journal of clinical and experimental pathology - 1 Jan 2015

Wang Peng, Yang Yanjie, Yang Xiuxian, Qiu Xiaohui, Qiao Zhengxue, Wang Lin, Zhu Xiongzhao, Sui Hong, Ma Jingsong

Abstract excerpt

Major depressive disorder (MDD) is one of the most severe psychiatric disorders. The objective of this study was to explore the effects of CREB1 gene polymorphisms on risk of developing MDD and the joint effects of gene-environment interactions. Genotyping was performed by Taqman allelic discrimination assay among 586 patients and 586 healthy controls. A significant impact on rs6740584 genotype distribution was...

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PMID: 25755794
PMCID: PMC4348828

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