Article
Genetic analyses of the endocannabinoid pathway in association with affective phenotypic variants.
Neuroscience letters - 23 Jan 2021
Lazary Judit, Eszlari Nora, Kriko Eszter, Tozser Dora, Dome Peter, Deakin J F William, Juhasz Gabriella, Bagdy Gyorgy
Abstract excerpt
BACKGORUND: Increasing experimental data confirm the crucial role of the endocannabinoid (eCB) system in the regulation of stress response and emotional processes. Despite of the fact, that genetically determined vulnerability for stress is a widely accepted concept in the pathomechanism of affective disorders, replicable human genetic results with interaction analyses of early life trauma and eCB genes are rare....
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