Article
Endosomal Wnt signaling proteins control microtubule nucleation in dendrites.
PLoS biology - 1 Mar 2020
Weiner Alexis T, Seebold Dylan Y, Torres-Gutierrez Pedro, Folker Christin, Swope Rachel D, Kothe Gregory O, Stoltz Jessica G, Zalenski Madeleine K, Kozlowski Christopher, Barbera Dylan J, Patel Mit A, Thyagarajan Pankajam, Shorey Matthew, Nye Derek M R, Keegan Matthew, Behari Kana, Song Song, Axelrod Jeffrey D, Rolls Melissa M
Abstract excerpt
Dendrite microtubules are polarized with minus-end-out orientation in Drosophila neurons. Nucleation sites concentrate at dendrite branch points, but how they localize is not known. Using Drosophila, we found that canonical Wnt signaling proteins regulate localization of the core nucleation protein γTubulin (γTub). Reduction of frizzleds (fz), arrow (low-density lipoprotein receptor-related protein [LRP] 5/6),...
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