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Article

Spatial regulation of microtubule disruption during dendrite pruning in Drosophila.

Development (Cambridge, England) - 11 May 2018

Herzmann Svende, Götzelmann Ina, Reekers Lea-Franziska, Rumpf Sebastian

Abstract excerpt

Large-scale neurite pruning is an important specificity mechanism during neuronal morphogenesis. Drosophila sensory neurons prune their larval dendrites during metamorphosis. Pruning dendrites are severed in their proximal regions, but how this spatial information is encoded is not clear. Dendrite severing is preceded by local breakdown of dendritic microtubules through PAR-1-mediated inhibition of Tau. Here, we...

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PMID: 29712642
DOI: 10.1242/dev.156950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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