Article
Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes.
Nature cell biology - 1 Oct 2008
Satoh Daisuke, Sato Daichi, Tsuyama Taiichi, Saito Motoki, Ohkura Hiroyuki, Rolls Melissa M, Ishikawa Fuyuki, Uemura Tadashi
Abstract excerpt
Dendrites allow neurons to integrate sensory or synaptic inputs, and the spatial disposition and local density of branches within the dendritic arbor limit the number and type of inputs. Drosophila melanogaster dendritic arborization (da) neurons provide a model system to study the genetic programs underlying such geometry in vivo. Here we report that mutations of motor-protein genes, including a dynein subunit...
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