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Article

Axon Termination, Pruning, and Synaptogenesis in the Giant Fiber System of Drosophila melanogaster Is Promoted by Highwire.

Genetics - 1 Mar 2017

Borgen Melissa, Rowland Kimberly, Boerner Jana, Lloyd Brandon, Khan Aruna, Murphey Rodney

Abstract excerpt

The ubiquitin ligase Highwire has a conserved role in synapse formation. Here, we show that Highwire coordinates several facets of central synapse formation in the Drosophila melanogaster giant fiber system, including axon termination, axon pruning, and synaptic function. Despite the similarities to the fly neuromuscular junction, the role of Highwire and the underlying signaling pathways are distinct in the...

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Identifiers

PMID: 28100586
DOI: 10.1534/genetics.116.197343
PMCID: PMC5340335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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