Article
Cystic renal-epithelial derived induced pluripotent stem cells from polycystic kidney disease patients.
Stem cells translational medicine - 1 Apr 2020
Kenter Annegien T, Rentmeester Eveline, van Riet Job, Boers Ruben, Boers Joachim, Ghazvini Mehrnaz, Xavier Vanessa J, van Leenders Geert J L H, Verhagen Paul C M S, van Til Marjan E, Eussen Bert, Losekoot Monique, de Klein Annelies, Peters Dorien J M, van IJcken Wilfred F J, van de Werken Harmen J G, Zietse Robert, Hoorn Ewout J, Jansen Gert, Gribnau Joost H
Abstract excerpt
Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease, leading to kidney failure in most patients. In approximately 85% of cases, the disease is caused by mutations in PKD1. How dysregulation of PKD1 leads to cyst formation on a molecular level is unknown. Induced pluripotent stem cells (iPSCs) are a powerful tool for in vitro modeling of genetic disorders. Here, we...
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