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Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD

30 Nov 2023

Abstract excerpt

In autosomal dominant polycystic kidney disease (ADPKD), renal cyst lesions predominantly arise from collecting ducts (CDs). However, relevant CD cyst models using human cells are lacking. Although previous reports have generated in vitro renal tubule cyst models from human induced pluripotent stem cells (hiPSCs), therapeutic drug candidates for ADPKD have not been identified. Here, by establishing expansion...

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PMID: 38039961
DOI: 10.1016/j.celrep.2023.113431

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