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Article

Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells.

PloS one - 1 Jan 2012

Cheng Li-Tao, Nagata Shogo, Hirano Kunio, Yamaguchi Shinpei, Horie Shigeo, Ainscough Justin, Tada Takashi

Abstract excerpt

Induced pluripotent stem cells (iPSCs) generated by epigenetic reprogramming of personal somatic cells have limited therapeutic capacity for patients suffering from genetic disorders. Here we demonstrate restoration of a genomic mutation heterozygous for Pkd1 (polycystic kidney disease 1) deletion (Pkd1(+/-) to Pkd1(+/R+)) by spontaneous mitotic recombination. Notably, recombination between homologous chromosomes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polycystic Kidney, Autosomal Dominant

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Source

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Identifiers

PMID: 22347511
DOI: 10.1371/journal.pone.0032018
PMCID: PMC3276537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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