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Article

Rapid target validation in a Cas9-inducible hiPSC derived kidney model

16 Aug 2021

Abstract excerpt

Recent advances in induced pluripotent stem cells (iPSCs), genome editing technologies and 3D organoid model systems highlight opportunities to develop new in vitro human disease models to serve drug discovery programs. An ideal disease model would accurately recapitulate the relevant disease phenotype and provide a scalable platform for drug and genetic screening studies. Kidney organoids offer a high cellular...

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PMID: 34400685
DOI: 10.1038/s41598-021-95986-5

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