Article
A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs.
Biochemical and biophysical research communications - 3 Sept 2020
Shimizu Tatsuya, Mae Shin-Ichi, Araoka Toshikazu, Okita Keisuke, Hotta Akitsu, Yamagata Kunihiro, Osafune Kenji
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder which manifests progressive renal cyst formation and leads to end-stage kidney disease. Around 85% of cases are caused by PKD1 heterozygous mutations, exhibiting relatively poorer renal outcomes than those with mutations in other causative gene PKD2. Although many disease models have been proposed for ADPKD, the pre-symptomatic...
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