Article
Generation of induced pluripotent stem cells derived from an autosomal dominant polycystic kidney disease patient with a p.Ser1457fs mutation in PKD1.
Stem cell research - 1 Oct 2017
Huang Ching-Ying, Ho Ming-Ching, Lee Jia-Jung, Hwang Daw-Yang, Ko Hui-Wen, Cheng Yu-Che, Hsu Yu-Hung, Lu Huai-En, Chen Hung-Chun, Hsieh Patrick C H
Abstract excerpt
Autosomal dominant polycystic kidney disease is one of the most prevalent forms of inherited cystic kidney disease, and can be characterized by kidney cyst formation and enlargement. Here we report the generation of a Type 1 ADPKD disease iPS cell line, IBMS-iPSC-012-12, which retains the conserved deletion of PKD1, normal karyotype and exhibits the properties of pluripotent stem cells such as ES-like morphology,...
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