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Article

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.

Cell reports - 10 Mar 2020

Lüningschrör Patrick, Werner Georg, Stroobants Stijn, Kakuta Soichiro, Dombert Benjamin, Sinske Daniela, Wanner Renate, Lüllmann-Rauch Renate, Wefers Benedikt, Wurst Wolfgang, D'Hooge Rudi, Uchiyama Yasuo, Sendtner Michael, Haass Christian, Saftig Paul, Knöll Bernd, Capell Anja, Damme Markus

Abstract excerpt

Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiological function of TMEM106B, we generated TMEM106B-deficient mice. These mice develop proximal axonal swellings caused by drastically enlarged LAMP1-positive vacuoles,...

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Identifiers

PMID: 32160553
DOI: 10.1016/j.celrep.2020.02.060

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Related research

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The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.PMID 32160553Read ↗

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in miceSemantic proximity Read ↗

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and functionSemantic proximity Read ↗

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Semantic proximity Read ↗

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.Semantic proximity Read ↗

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.Semantic proximity Read ↗

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturationSemantic proximity Read ↗

TFEB-depletion rescues TMEM106B-related myelin defects in zebrafishSemantic proximity Read ↗

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.Semantic proximity Read ↗

Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulationSemantic proximity Read ↗

Physiological and pathological functions of TMEM106B in neurodegenerative diseases.Semantic proximity Read ↗

TMEM106B aggregation in neurodegenerative diseases: linking genetics to function.Semantic proximity Read ↗

What we know about TMEM106B in neurodegeneration.Semantic proximity Read ↗

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