Article

TFEB-depletion rescues TMEM106B-related myelin defects in zebrafish

2025-10-11

Abstract excerpt

<h4>ABSTRACT</h4> Lysosomal transmembrane protein TMEM106B is genetically and neuropathologically implicated in a range of neurodegenerative diseases. Unexpectedly, the recurrent de novo TMEM106B variant p.(Asp252Asn) causes a hypomyelinating disorder. TMEM106B controls lysosomal positioning in neurons, but its role in white matter health is not fully understood. To study the role of TMEM106B in myelination in vi...

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Literature Corpus work: 1fee0aa8-aa75-5e6d-8f09-cabda58034d4
DOI: 10.1101/2025.10.10.681547

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