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Article

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2020

Johnston Andrea N, Ma Yuyong, Liu Hua, Liu Shuzhen, Hanna-Addams Sarah, Chen She, Chen Chuo, Wang Zhigao

Abstract excerpt

Necroptosis is a regulated necrotic cell death pathway involved in development and disease. Its signaling cascade results in the formation of disulfide bond-dependent amyloid-like polymers of mixed lineage kinase domain-like protein (MLKL), which mediate proinflammatory cell membrane disruption. We screened compound libraries provided by the National Cancer Institute and identified a small-molecule inhibitor of...

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PMID: 32156734
DOI: 10.1073/pnas.1916503117
PMCID: PMC7104336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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