Article
Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant.
Blood - 1 Mar 2004
Wan Tao, Zhou Xiangyang, Chen Guoyou, An Huazhang, Chen Taoyong, Zhang Weiping, Liu Shuxun, Jiang Yingming, Yang Feng, Wu Yanfeng, Cao Xuetao
Abstract excerpt
Heat shock proteins (HSPs) are reported to act as effective adjuvants to elicit anti-tumor and anti-infection immunity. Here, we report that Hsp70-like protein 1 (Hsp70L1), a novel HSP derived from human dendritic cells (DCs), has potent adjuvant effects that polarize responses toward Th1. With a calculated molecular weight of 54.8 kDa, Hsp70L1 is smaller in size than Hsp70 but resembles it both structurally and...
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