Article
MTHFR rs1801133 polymorphism is associated with increased risk of B-cell precursor lymphoblastic leukaemia with recurrent genetic aberrations of fetal origin.
Cancer epidemiology - 1 Apr 2020
Chung-Filho Alython Araujo, Brisson Gisele Dallapicola, Vieira Tállita Mecianny Farias, Chagas-Neto Paulo, Soares-Lima Sheila Coelho, Pombo-de-Oliveira Maria S
Abstract excerpt
BACKGROUND: Childhood acute lymphoblastic leukaemia (ALL) is a heterogeneous disease associated with multiple risk factors including genetic susceptibility. Polymorphisms in folate genes have been associated with a protective effect against ALL, although some studies contradict these findings. We aimed to test whether there is an association between the MTHFR rs1801133 variant and the occurrence of B-cell...
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