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Article

A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children.

Pediatric blood & cancer - 1 Apr 2012

Yan Jingrong, Yin Ming, Dreyer ZoAnn E, Scheurer Michael E, Kamdar Kala, Wei Qingyi, Okcu M Fatih

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms have been implicated in childhood acute lymphoblastic leukemia (ALL) risk, but previously published studies were inconsistent and recent meta-analyses were not adequate. PROCEDURES: In a meta-analysis of 21 publications with 4,706 cases and 7,414 controls, we used more stringent inclusion method and summarized data on...

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Identifiers

PMID: 21495160
DOI: 10.1002/pbc.23137

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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