The association of methylenetetrahydrofolate reductase genotypes with the risk of childhood leukemia in Taiwan.

doi:10.1371/journal.pone.0119776

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Article

The association of methylenetetrahydrofolate reductase genotypes with the risk of childhood leukemia in Taiwan.

PloS one - 1 Jan 2015

Pei Jen-Sheng, Hsu Chin-Mu, Tsai Chia-Wen, Chang Wen-Shin, Ji Hong-Xue, Hsiao Chieh-Lun, Miao Chia-En, Hsu Yuan-Nian, Bau Da-Tian

Abstract excerpt

BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most prevalent type of pediatric cancer, the causes of which are likely to involve an interaction between genetic and environmental factors. To evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) on childhood ALL risk in Taiwan, two well-known polymorphic genotypes of MTHFR, C677T (rs1801133) and A1298C...

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Identifiers

PMID: 25793509
DOI: 10.1371/journal.pone.0119776
PMCID: PMC4368437

Genes

MTHFR

Variants

rs1801133
rs1801133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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