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Article

The methylenetetrahydrofolate reductase 677T-1298C haplotype is a risk factor for acute lymphoblastic leukemia in children.

Medicine - 1 Dec 2017

Kałużna Ewelina Maria, Strauss Ewa, Świątek-Kościelna Bogna, Zając-Spychała Olga, Gowin Ewelina, Nowak Jerzy S, Rembowska Jolanta, Januszkiewicz-Lewandowska Danuta

Abstract excerpt

The etiology of acute lymphoblastic leukemia (ALL) is complex, linked with both environmental exposures and genetic factors. Functional variants of the methylenetetrahydrofolate reductase (MTHFR) gene result in disturbance in folate metabolism and may affect susceptibility to cancer. The study was performed to evaluate whether MTHFR C677T and A1298C polymorphisms, analyzed separately and together, are associated...

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Identifiers

PMID: 29390492
DOI: 10.1097/MD.0000000000009290
PMCID: PMC5758194

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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