Article
Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014
Kreile Madara, Rots Dmitrijs, Piekuse Linda, Cebura Elizabete, Grutupa Marika, Kovalova Zhanna, Lace Baiba
Abstract excerpt
BACKGROUND: Acute lymphoblastic leukemia (ALL) is a complex disease caused by interactions between hazardous exogenous or/and endogenous agents and many mild effect inherited susceptibility mutations. Some of them are known, but their functional roles still requireinvestigation. Age is a recognized risk factor; children with disease onset after the age of ten have worse prognosis, presumably also triggered by...
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