Article
Differential DNA methylation of vocal and facial anatomy genes in modern humans.
Nature communications - 4 Mar 2020
Gokhman David, Nissim-Rafinia Malka, Agranat-Tamir Lily, Housman Genevieve, García-Pérez Raquel, Lizano Esther, Cheronet Olivia, Mallick Swapan, Nieves-Colón Maria A, Li Heng, Alpaslan-Roodenberg Songül, Novak Mario, Gu Hongcang, Osinski Jason M, Ferrando-Bernal Manuel, Gelabert Pere, Lipende Iddi, Mjungu Deus, Kondova Ivanela, Bontrop Ronald, Kullmer Ottmar, Weber Gerhard, Shahar Tal, Dvir-Ginzberg Mona, Faerman Marina, Quillen Ellen E, Meissner Alexander, Lahav Yonatan, Kandel Leonid, Liebergall Meir, Prada María E, Vidal Julio M, Gronostajski Richard M, Stone Anne C, Yakir Benjamin, Lalueza-Fox Carles, Pinhasi Ron, Reich David, Marques-Bonet Tomas, Meshorer Eran, Carmel Liran
Abstract excerpt
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely...
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