Article
Bottleneck Size-Dependent Changes in the Genetic Diversity and Specific Growth Rate of a Rotavirus A Strain.
Journal of virology - 4 May 2020
Kadoya Syun-Suke, Urayama Syun-Ichi, Nunoura Takuro, Hirai Miho, Takaki Yoshihiro, Kitajima Masaaki, Nakagomi Toyoko, Nakagomi Osamu, Okabe Satoshi, Nishimura Osamu, Sano Daisuke
Abstract excerpt
RNA viruses form a dynamic distribution of mutant swarms (termed "quasispecies") due to the accumulation of mutations in the viral genome. The genetic diversity of a viral population is affected by several factors, including a bottleneck effect. Human-to-human transmission exemplifies a bottleneck effect, in that only part of a viral population can reach the next susceptible hosts. In the present study, two...
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