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Article

Inferring Transmission Bottleneck Size from Viral Sequence Data Using a Novel Haplotype Reconstruction Method.

Journal of virology - 16 Jun 2020

Ghafari Mahan, Lumby Casper K, Weissman Daniel B, Illingworth Christopher J R

Abstract excerpt

The transmission bottleneck is defined as the number of viral particles that transmit from one host to establish an infection in another. Genome sequence data have been used to evaluate the size of the transmission bottleneck between humans infected with the influenza virus; however, the methods used to make these estimates have some limitations. Specifically, viral allele frequencies, which form the basis of...

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Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Influenza A virus

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Share to Sequence Analysis, DNA

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Source

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Identifiers

PMID: 32295920
DOI: 10.1128/JVI.00014-20
PMCID: PMC7307158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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